Publications

Publications

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Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Cell. 2018 Aug 23   ↓   🔗    

Read news coverage in Science Daily and a highlight in Nature Reviews Neuroscience

> Here we defined a novel molecular classification scheme for spiral ganglion neurons (SGNs) using single-cell RNA sequencing (scRNA-seq) in mice. Employing insights learned from SGN transcriptomic profiles, we charted the emergence of SGN subtype identities during development and their loss in old age. Perturbation of spontaneous activity altered SGN identities even after birth, revealing an intriguing developmental phenomenon whereby neuronal subtype proportions are influenced by circuit activity generated in the absence of extrinsic sound.

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Shrestha BR, Goodrich LV. Wiring the cochlea for sound perception. The Oxford Handbook of the Auditory Brainstem. Sep 2019   🔗
> In this book chapter, we provide an overview of the development of spiral ganglion neurons focusing on molecular and cellular factors influencing their differentiation and wiring.